1) Staring at the Mountain [Game of Thrones]
Ser Gregor "The Mountain" Clegane is one of the most terrifying men in Game of Thrones, being a behemoth of a man who is one of the most brutal fighters in Westeros. The Mountain is also a walking war crime, and is sent by Tywin Lannister (his liege lord) to "harass" the Riverlands countryside during the War of the Five Kings. He takes this opportunity to rape, torture, and butcher civilians and soldiers alike to his liking.
In the middle of the second season, Arya Stark (disguised as a peasant) and her friends are caught by the Mountain's men, who pen her and other refugees up in Harrenhal. Every day, the Mountain selects one random prisoner to be "questioned". No matter how much or how little they know, the victim always gets tortured to death.
At one point, Arya's friend, Hot Pie, learns from a fellow inmate a way to avoid getting tortured: Don't look away from the Mountain when he selects his victim. The inmate apparently did this for weeks, and hasn't been chosen. Hot Pie and this inmate both stare the Mountain down when he appears next... only for the inmate to be chosen. The inmate can only panic as he realizes he never was right. Hot Pie promptly pisses himself when he realizes there's truly no way to avoid being tortured to death.
2) Gaming the Visitor's Curse [Look Outside]
Look Outside is a game where you play as a 30-something shut-in in the middle of a disaster. You learn from your neighbor that something has happened outside the apartment across the world. Nobody knows what it is, but some entity called "The Visitor" has appeared in the sky. Anyone who attempts to look at or even think about the Visitor too hard becomes "Cursed", causing them to mutate into some strange form.
The Curses range from "Eldritch" to "surprisingly mundane". You can meet people who have kept their sanity even as massive tentacle monsters, or you can meet people whose sanity has completely shattered as their bodies changed. Some of the Curses are ironic in nature, while others serve as an extension of your psyche (such as an anxiety-ridden character becoming a manifestation of drowning, showing how they feel with their disorder).
Some characters try to put this theory to the test and become their "true forms". It seldom works like that. One notable character, Louis, is a furry who thought that his fursuit would protect him from the effects of the Visitor. He tells the main character that even if he got Cursed, he wouldn't mind, because he thought that it would transform him into his Fursona.
It backfired immensely: he instead became a human fused to the lining of his suit, and his suit is rotting his body inside. (You can see his former body trying to claw its way out of the jaw). Despite his denial, this is clearly incredibly painful for him, and the exact opposite of what he wants Louis gradually loses his sanity as you talk to him throughout the game, and his suit instead becomes multiple living chunks of the costume after you fight him.
This is merely one of the examples that reminds the player that being Cursed is an absolute crapshoot. It's not a shortcut to superpowers, nor is it a guaranteed "real version" of yourself. You just as likely have a chance of becoming a barely-sentient worm or a pile of faces, your mind completely gone.
3) Using Salt [Crossed]
TW: Rape/Extreme Violence (I'm not kidding here)
Probably the most iconic moment from Crossed (and let's be so for real, a lot of people put the comic down after this scene).
Crossed features the survivors of a horrific apocalypse: a massive disease has overtaken the planet, causing the afflicted to develop a cross-shaped rash on their face. These victims become a slave to their immediate impulses, which all tend to be "find the survivors and rape them to death in increasingly-horrific ways". In the first issue, a survivor, Joel, discusses an incident where he saw a Crossed react badly to table salt falling on his face. He thinks the Crossed have a weakness to salt, and that this might be a solution to the end of the world, a "magic bullet". Everybody tells him this is a dumb move, and he'd likely risk his wife and daughter's wife if he tried to implement it.
When the crew get ambushed by the Crossed, Joel's wife twists her leg. She begs him to take his daughter and shoot her, lest she die horribly. He refuses to leave her, and pours a salt circle instead as the Crossed approach. They stand outside the circle.
Smash cut to a full splash panel of Joel and his family getting raped, hacked to pieces, and slowly killed by the Crossed. In her last moments, his wife bitterly curses him out for being an idiot. There's a reason I'm not putting a picture up.
The entire scene only exists to remind the reader not to expect anything good from here on out, and this isn't the sort of story about restoring humanity. It's about surviving, and how even that's probably not going to work.